The Prostate Health Index (phi Can Help Reduce Unnecessary Biopsies

The Prostate Health Index is an FDA approved blood test that can help differentiate prostate cancer from benign conditions in men with elevated PSA. The Prostate Health Index utilizes three different PSA markers (PSA, freePSA, and p2PSA) as part of a sophisticated algorithm to more reliably determine the probability of cancer in patients with elevated PSA levels and can help men and their physicians decide if a prostate biopsy is indicated. 2-5

The Prostate Health Index is now available through the AVRT telehealth program. AVRT is a comprehensive telehealth program that uses advanced diagnostics, evidence based clinical protocols and online physician supervision to help patients stay well and reduce the risk of developing cancer and other chronic diseases.

Am I a Candidate?

Male patients may be a candidate for the Prostate Index Test if they are age 50 years and older with an elevated PSA between 4ng/ml and 10ng/ml. Peer-reviewed published studies support the use of Prostate Health Index in men with total PSA values as low as 2 ng/ml.1-4

The Prostate Health Index is included in the National Comprehensive Cancer Network (NCCN) Guideline for Prostate Cancer Early Detection as a blood test to improve specificity for prostate cancer detection. 6

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AVRT is a New, Revolutionary Approach to Healthcare!

AVRT is a comprehensive, physician supervised telehealth program which uses advanced diagnostics to help detect cancer and chronic disease in the earliest stages when they are highly treatable, along with lifestyle and pharmaceutical management.

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Our Physicians Are Leaders in the Field of Cancer 

In order to help prevent cancer, we first must understand cancer and how it functions. That’s why AVRT is led by leading oncologists, who can provide insights into nutrition, lifestyle modifications and medications to help minimize your risk of developing cancer. AVRT physicians and scientists are experts in the field of cancer, inflammation and metabolism and develop patient-centric, personalized care plans to optimize patient health. We are committed to the singular goal of prevention: keeping people healthy and reducing the risk of cancer & chronic disease. ​Meet a few of our physicians below.tween.

Charles J. Meakin, MD, MHA

Charles J. Meakin, III, M.D., MHA received his medical degree from the University of Cincinnati College of Medicine, followed by a residency in Radiation Oncology at Stanford University Medical Center, Stanford, CA. Board Certified in Radiation Oncology, he also completed a Masters in Health Administration from St. Mary’s College of Moraga, Moraga, CA.

Christy M. Kesslering, M.D.

Christie Kesslering, M.D. received her medical degree from the Stritch School of Medicine, Loyola University, Maywood, IL, followed by a residency in Radiation Oncology at the University of Wisconsin, Madison, WI. She is Board Certified in Radiation Oncology.

Zoraida Mendez, M.D.

Zoraida Mendez, M.D. received her medical degree at Universidad Nacional Pedro Henriquez Urena, Santo Domingo, Dominican Republic,  followed by a residency in Internal Medicine at Saint Elizabeth Hospital of Youngstown, OH. She completed her Fellowship in Hematology and Oncology at the Cleveland Clinic Foundation in Cleveland, Ohio.

Paul Zhang, M.D., Ph.D

Paul Zhang, M.D., Ph.D. is a physician-scientist board-certified in medical oncology and internal medicine. Dr. Zhang received his medical degrees from Hebei Medical University and Beijing University. He completed his residency in Internal Medicine at Columbia University, New York, NY, a Clinical Fellowship at Yale University, New Haven, CT and a Cancer Research Fellowship at Memorial Sloan-Kettering Cancer Center, New York, NY.

What Kinds of Testing Do You Offer?

AVRT works with StageZero Life Sciences, a CLIA Certified, CAP Accredited High Complexity Laboratory in Richmond, VA to provide the most advanced testing for early cancer detection. Tests available through Stage Zero include:

AVRT Panel

A comprehensive panel including inflammatory markers and metabolic function tests to help identify early warning signs of chronic disease and metabolic conditions.  ​

ARISTOTLE

Aristotle is a blood-based mRNA Multi-Cancer Panel for Identifying the molecular signatures of multiple cancers from a single blood draw(7)

ColonSentry

ColonSentry® is a blood test that uses advanced mRNA gene expression technology to help identify Colorectal Cancer (CRC) early when it’s most treatable (8).

BreastSentry

BreastSentry is a blood test that can help identify if a woman has an increased risk for developing breast cancer (9).

PHI

The Prostate Health Index is an FDA approved blood test that can help men with elevated PSA to differentiate benign prostate conditions from prostate cancer (2,3).

How it works

Fill out any of the contact forms above to set up a FREE consult with a case manager to learn more about the program.


  1. Tell us more about you by completing a health profile form prior to your first call with a physician.
  2. Attend your initial consultation with a physician to review your medical records, concerns and goals.
  3. Get tested, receive your test results and review with an AVRT physician. 

Should you choose to move into our AVRT program, you’ll get an individualized care plan to help you continue your journey to health.

References

  1.  Biddle C, Brasel A, Underwood W 3rd, et al. Experiences of Uncertainty in Men With an Elevated PSA. Am J Mens Health. 2016;11(1):24-34.
  2. Catalona WJ, Partin AW, Sanda MG, et al. A Multi-Center Study of [−2]Pro-Prostate-Specific Antigen (PSA) in Combination with PSA and Free PSA for Prostate Cancer Detection in the 2.0 to 10.0 ng/mL PSA Range. The Journal of Urology. 2011;185(5):1650-1655. 
  3. Loeb S, Sanda MG, Broyles DL, et al. The Prostate Health Index Selectively Identifies Clinically Significant Prostate Cancer. The Journal of Urology. 2015;193(4):1163-1169 
  4. Huang YQ, Sun T, Zhong WD, et al. Clinical performance of serum [-2]proPSA derivatives, %p2PSA and PHI, in the detection and management of prostate cancer. Am J Clin Exp Urol  2014;2(4):343-350 
  5. Lepor A, Catalona WJ, Loeb S. The Prostate Health Index: Its Utility In Prostate Cancer Detection. The Urologic Clinics of North America. 2016;43(1):1-6. 
  6. National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology: Prostate Cancer Early Detection. Version 2.2018 – April 5, 2018 
  7. Dempsey A, Chao S, Stamatiou D, et al., Aristotle: A single blood test for pan-cancer screening. Journal of Clinical Oncology. 2020; 38:15_suppl, e15037-e15037
  8. Liew CC, Ma J, Tang HC, et al. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med. 2006 Mar;147(3):126-32.
  9. Melander O, Belting M, Manjer J, et al. Validation of plasma proneurotensin as a novel biomarker for the prediction of incident breast cancer. Cancer Epidemiology and Prevention Biomarkers 23.8 (2014): 1672-1676.

Aristotle, ColonSentry, & BreastSentry tests were developed, and their performance characteristics determined by Stage Zero Life Sciences, Inc.; they have not been cleared or approved by the US Food and Drug Administration. These tests were performed in a CLIA certified laboratory and are intended for clinical purposes. The Aristotle, Prostate Health Index, ColonSentry, & BreastSentry tests must be ordered by and used only in consultation with a healthcare provider.